Abstract
A series of N(1)- and N(2)-propargylphenelzine derivatives and analogues (1-7) was synthesized. In addition to their activity as monoamine oxidase inhibitors, two of the compounds, N(1)- and N(2)-propargylphenelzines (3 and 6), were found to be potent at preventing DSP-4-induced noradrenaline (NA) depletion in mouse hippocampus, suggesting that they have neuroprotective properties.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Hippocampus / drug effects
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Hippocampus / metabolism
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Mice
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Monoamine Oxidase Inhibitors / chemical synthesis
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Monoamine Oxidase Inhibitors / chemistry
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Neuroprotective Agents / chemical synthesis*
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Neuroprotective Agents / chemistry
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Norepinephrine / metabolism
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Phenelzine / analogs & derivatives
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Phenelzine / chemical synthesis*
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Phenelzine / chemistry
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Phenelzine / pharmacology
Substances
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Monoamine Oxidase Inhibitors
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N-propargylphenelzine
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Neuroprotective Agents
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Phenelzine
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Norepinephrine