Synthesis of N-propargylphenelzine and analogues as neuroprotective agents

Bioorg Med Chem Lett. 2001 Oct 22;11(20):2715-7. doi: 10.1016/s0960-894x(01)00549-2.

Abstract

A series of N(1)- and N(2)-propargylphenelzine derivatives and analogues (1-7) was synthesized. In addition to their activity as monoamine oxidase inhibitors, two of the compounds, N(1)- and N(2)-propargylphenelzines (3 and 6), were found to be potent at preventing DSP-4-induced noradrenaline (NA) depletion in mouse hippocampus, suggesting that they have neuroprotective properties.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Hippocampus / drug effects
  • Hippocampus / metabolism
  • Mice
  • Monoamine Oxidase Inhibitors / chemical synthesis
  • Monoamine Oxidase Inhibitors / chemistry
  • Neuroprotective Agents / chemical synthesis*
  • Neuroprotective Agents / chemistry
  • Norepinephrine / metabolism
  • Phenelzine / analogs & derivatives
  • Phenelzine / chemical synthesis*
  • Phenelzine / chemistry
  • Phenelzine / pharmacology

Substances

  • Monoamine Oxidase Inhibitors
  • N-propargylphenelzine
  • Neuroprotective Agents
  • Phenelzine
  • Norepinephrine